HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → 2-Bromo-4-(trifluoromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyridine | HCID 144958 | — |
| Solvent | Propionitrile | HCID 7854 | — |
| Product | 2-Bromo-4-(trifluoromethyl)pyridine | HCID 2781543 | — |
Reaction Steps
A mixture of 2-chloro-4-(trifluoromethyl)pyridine (2.70 g, 14.9 mmol) and bromotrimethylsilane (3.90 mL, 29.6 mmol) in propanenitrile (15.0 mL) was heated under reflux for 22 h. The product (very volatile) was carefully rotary evaporated to give 4.07 g (propanenitrile contained) of thick light brown suspension w/o further purification. LC-MS calculated for C6H3BrF3N (M+H) 226.9; found 225.9/227.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563582B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-01fd36e7b37347958540c95b400cfd87 |
| Source note | uspto-grants-2013_10 |