Acetic Anhydride → HCID 58320501, compound

HRID 1044652Notes

Reaction equation

HRID 1044652 reaction equation
[NH2:1][C:2]1[C:3]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[N:4][C:5]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[C:32](OC(=O)C)(=[O:34])[CH3:33]>N1C=CC=CC=1>[C:32]([NH:1][C:2]1[C:7]([N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)=[N:6][C:5]([N:14]2[CH2:19][CH2:18][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)=[N:4][C:3]=1[N:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1)(=[O:34])[CH3:33]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 442508375-Amino-2-(4-phenylpiperazin-1-yl)-4,6-dimorpholinopyrimidine

Product 1

HCID 58320501HCID 58320501, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 1049PyridineCatalyst

Procedure

The synthesis method shall be explained concretely, and in order, below. A solution of 5-amino-2-(4-phenylpiperazin-1-yl)-4,6-dimorpholinopyrimidine (700 mg, 1.64 mmol), acetic anhydride (5 ml), and pyridine (a few drops) was agitated for 1 hour at 60 degrees Celsius. The deposited solid was captured by filtering, washed with ether, and 330 mg of 5-acetylamino-4,6-dimorpholino-2-(4-phenylpiperazin-1-yl)pyrimidine was obtained (43% yield). The melting point measurement result, the MS measurement result, and the NMR data for the obtained Compound 77 are shown below.

Workup

  1. customThe synthesis method
  2. filtrationby filtering
  3. washwashed with ether

Sources & evidence

ORD record
ord-9b67a73da27e44c1af1de8b7ed951f40
Source dataset
uspto-grants-2013_10
Patent number
US08563715B2

Reaction notes

Loading…