反应详情

The synthesis method shall be explained concretely, and in order, below. A solution of 5-amino-2-(4-phenylpiperazin-1-yl)-4,6-dimorpholinopyrimidine (700 mg, 1.64 mmol), acetic anhydride (5 ml), and pyridine (a few drops) was agitated for 1 hour at 60 degrees Celsius. The deposited solid was captured by filtering, washed with ether, and 330 mg of 5-acetylamino-4,6-dimorpholino-2-(4-phenylpiperazin-1-yl)pyrimidine was obtained (43% yield). The melting point measurement result, the MS measurement result, and the NMR data for the obtained Compound 77 are shown below.

1. customThe synthesis method
2. filtrationby filtering
3. washwashed with ether