HCID 76759879, compound → HCID 66913060, compound

Participants

Reaction Steps

The synthesis method shall be explained concretely, and in order, below. 5-amino-2-[4-(4-diethylaminophenyl)butan-1,3-dienyl]-4,6-dimorpholinopyrimidine (500 mg, 1.08 mmol) (Compound 144) was dissolved in ethanol (30 ml), 300 mg of Pd/C was added, and catalytic reduction was carried out for 18 hours at room temperature. The Pd/C was filtered out of the reaction liquid using celite, the filtrate was taken and the solvent was distilled away under reduced pressure. The residue was separated and purified by silica gel chromatography (hexane:ethyl acetate=1:1), and 131.4 mg of 5-amino-2-[4-(4-diethylaminophenyl)butyl]-4,6-dimorpholino pyrimidine (Compound 145) was obtained (yield 26%). The MS measurement result, and the NMR data for the obtained Compound 145 are shown below.

Provenance & Evidence