HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(4-Chloroquinazolin-6-yl)furan-2-carbaldehyde hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(4-Hydroxy-6-quinazolinyl)furan-2-carbaldehyde | HCID 136162616 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 5-(4-Chloroquinazolin-6-yl)furan-2-carbaldehyde hydrochloride | HCID 56649814 | — |
Reaction Steps
A mixture of the compound of formula (IX) (0.6 g, 2 5 mmol), SOCl2 (15 mL) and one drop of DMF was heated under reflux until the reaction was complete (TLC analysis). The volatile components were evaporated (including SOCl2) to provide crude (Xa).HCl (0.9 g) that could be used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563719B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-073f6506520e450a982a162a90561007 |
| Source note | uspto-grants-2013_10 |