Nitrogen → [5-(2-Methyl-[1,3]dioxolan-2-yl)-thiazol-2-yl]-methanol

Participants

Reaction Conditions

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), 5-(2-methyl-[1,3]dioxolan-2-yl)thiazole-2-carbaldehyde (5.12 g, 25.70 mmol) was dissolved in MeOH (60 mL). NaBH4 (1.26 g, 31.89 mmol) was added portionwise at 0° C. and the reaction mixture stirred at 0° C. for 1 h. Water was added and the mixture extracted with EA (3×). The combined org. extracts were dried over Na2SO4, filtered, and the solvents were removed under reduced pressure to give the title compound as an orange oil. TLC:rf (1:1 hept-EA)=0.31. LC-MS-conditions 02: tR=0.64 min; [M+H]+=202.52.

Provenance & Evidence