3-(Cyclopropanecarbonyl)benzonitrile → HCID 74424984, compound

HRID 1044827Notes

Reaction equation

HRID 1044827 reaction equation
[CH:1]1([C:4]([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[C:9]#[N:10])=O)[CH2:3][CH2:2]1.[F:14][C:15]([F:35])([F:34])[O:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([N:26]2[CH2:31][CH2:30][CH:29]([O:32][NH2:33])[CH2:28][CH2:27]2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[CH:1]1([C:4](=[N:33][O:32][CH:29]2[CH2:28][CH2:27][N:26]([S:23]([C:20]3[CH:19]=[CH:18][C:17]([O:16][C:15]([F:35])([F:14])[F:34])=[CH:22][CH:21]=3)(=[O:24])=[O:25])[CH2:31][CH2:30]2)[C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[C:9]#[N:10])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 247240893-(Cyclopropanecarbonyl)benzonitrileHCID 67118448HCID 67118448, compound

Product 1

HCID 74424984HCID 74424984, compound

Procedure

3-(Cyclopropanecarbonyl)benzonitrile was coupled with O-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yl)hydroxylamine to give 3-(cyclopropyl(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxyimino)methyl)benzonitrile as a mixture of stereoisomers.

Sources & evidence

ORD record
ord-04c03ae5345d4dca9a9f4253a7fa8682
Source dataset
uspto-grants-2013_10
Patent number
US08563732B2

Reaction notes

Loading…