N-Hydroxyphthalimide → HCID 67118409, compound

Participants

Reaction Steps

Diethyl azodicarboxylate (40% in toluene, 1.0 ml, 2.2 mmol) was added to the mixture of 1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-ol (651 mg, 2.0 mmol), N-hydroxyphthalimide (359 mg, 2.2 mmol) and triphenylphosphine (577 mg, 2.2 mmol) in THF (8 ml) at 0° C. and stirred at room temperature for 2 days. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica (EtOAc/Hexanes 10/90-50/50) to give 2-(1-(4-(trifluoromethoxy)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione (390 mg, 40%).

Provenance & Evidence