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Acetonitrile → 4-(Heptafluoropropylthio)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Aminothiophenol | HCID 14510 | — |
| 反応物 | Perfluoropropyl iodide | HCID 33977 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(Heptafluoropropylthio)aniline | HCID 2052609 | 63.2% |
反応手順
To 20 ml of an acetonitrile solution of 1.25 g of 4-aminothiophenol and 1.11 g of triethylamine, 5.91 g of 1-iodoheptafluoro-n-propane was added, and the mixture was stirred at room temperature for 3 hours. The mixture was diluted with ether, washed with an aqueous solution of 1N sodium hydroxide and purified by silica gel column chromatography (eluent:hexane:ethyl acetate=4:1) to give 1.85 g (yield 63%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08563736B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-50a0107f3b2f4b59bcc74050bf60cc6f |
| 出典メモ | uspto-grants-2013_10 |