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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044855Generated: November 1, 2026

(R)-Tert-butyl 3-(bromomethyl)piperidine-1-carboxylate → 1,1-Dimethylethyl (3S)-3-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]methyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044855

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-Tert-butyl 3-(bromomethyl)piperidine-1-carboxylateHCID 40425280—
Reactant2-Butoxy-9-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)-8-methoxyadenineHCID 58306091—
ReactantHCID 178450370HCID 178450370—
Product1,1-Dimethylethyl (3S)-3-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]methyl}-1-piperidinecarboxylateHCID 67234123—

Reaction Steps

Prepared similarly to Intermediate 13 from 2-butoxy-8-methoxy-9H-purin-6-amine trifluoroacetate salt and 1,1-dimethylethyl (3R)-3-(bromomethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-edf48cdefd6f456fa16e99a8569882f4
Source noteuspto-grants-2013_10