反应详情

3-(2-Piperidinyl)-1-propanol (8.69 g, 60.7 mmol) was stirred in acetonitrile (90 ml) with triethylamine (10.40 mL, 74.6 mmol) under N2 and cooled in an ice bath. Benzyl chloroformate (9.53 ml, 66.7 mmol) was added dropwise. After complete addition the reaction was allowed to warm to ambient temperature and stirring then continued overnight. The suspension was filtered and the filtrate evaporated to dryness. The residue was partitioned between ethyl acetate and water. The organic phase was washed with saturated brine, passed through a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica (330 g silica RediSep column, loaded in DCM) using a 0-50% ethyl acetate in cyclohexane gradient over 40 mins. with a 50-100% flush of ethyl acetate on an ISCO Companion. No peaks were detected (254 nm, 280 nm) so the waste was evaporated in vacuo to recover the material. The material was re-columned using identical conditions as before but detecting at 220 nm and collecting all the eluent. The main product peak was collected and evaporated in vacuo to give the title compound as a yellow oil (6.15 g). LCMS (System B): tRET=2.46 min; MH+ 278

1. temperaturecooled in an ice bath
2. additionAfter complete addition the reaction
3. filtrationThe suspension was filtered
4. customthe filtrate evaporated to dryness
5. customThe residue was partitioned between ethyl acetate and water
6. washThe organic phase was washed with saturated brine
7. customevaporated to dryness
8. customThe residue was purified by chromatography on silica (330 g silica RediSep column, loaded in DCM)
9. customover 40 mins
10. customwith a 50-100% flush of ethyl acetate on an ISCO Companion
11. customwas evaporated in vacuo
12. customto recover the material
13. customcollecting all the eluent
14. customThe main product peak was collected
15. customevaporated in vacuo