反应详情

Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate (1.16 g, 2.336 mmol) in ethanol (130 ml) was hydrogenated over 10% palladium on carbon (0.497 g, 0.467 mmol) at ambient temperature overnight. The mixture was filtered through a Celite cartridge under N2, washed with EtOH and evaporated in vacuo to give the title compound as a cream solid (0.66 g). LCMS (System B): tRET=1.29 min; MH+ 363

1. filtrationThe mixture was filtered through a Celite cartridge under N2
2. washwashed with EtOH
3. customevaporated in vacuo