Phenylmethyl 3-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}1-piperidinecarboxylate → 2-(Butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine

HRID 1044875Notes

Reaction equation

HRID 1044875 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2C[CH2:22][CH2:21][CH2:20][NH:19]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].NC1N=C(OCCCC)N=C2C=1N=C(OC)N2CCC1CCCN(C(OCC2C=CC=CC=2)=O)C1>>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 58306107Phenylmethyl 3-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}1-piperidinecarboxylateHCID 583061842-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine

Product 1

HCID 583062622-(Butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 32 from phenylmethyl 3-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate.

Sources & evidence

ORD record
ord-2a3381f7472a4d81818669008033e82d
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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