Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044878Generated: October 31, 2026

Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate → Phenylmethyl 3-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044878

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantBenzyl 3-(2-bromoethyl)piperidine-1-carboxylateHCID 58306150—
ReactantHCID 178448286HCID 178448286—
ProductPhenylmethyl 3-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 58306208—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate salt and phenylmethyl 3-(2-bromoethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-000d05fffb9c4dda9de14f056ffff167
Source noteuspto-grants-2013_10