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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044883Generated: October 31, 2026

Benzyl 3-(3-bromopropyl)piperidine-1-carboxylate → Phenylmethyl 3-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044883

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 3-(3-bromopropyl)piperidine-1-carboxylateHCID 58306103—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178450370HCID 178450370—
ProductPhenylmethyl 3-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306094—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine trifluoroacetate and phenylmethyl 3-(3-bromopropyl)-1-piperidinecarboxylate. LCMS (System D): tRET=3.39 min; MH+ 497

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-450224e18eac449c9bbfb43c7beefa24
Source noteuspto-grants-2013_10