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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044892Generated: October 30, 2026

Phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate → Phenylmethyl 3-{4-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044892

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantPhenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylateHCID 58306246—
ReactantHCID 178448286HCID 178448286—
ProductPhenylmethyl 3-{4-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylateHCID 58306155—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate salt and phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-b27a300bbab540faa7485ea59da9f4cc
Source noteuspto-grants-2013_10