反应详情

Hydroxyacetonitrile (8.2 ml of a 70% w/w solution in water, 0.1 mol) was added to a solution of N-isopropylcyclopentanamine (11.43 g, 0.09 mol) (Preparation 23) in ethanol (60 ml). The reaction mixture was heated under reflux for 3 hours, allowed to cool and the solvent removed under reduced pressure. The residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume) to give the title compound (14.1 g) as a clear oil.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 3 hours
3. temperatureto cool
4. customthe solvent removed under reduced pressure
5. customThe residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume)