Isopropyl iodide → 2-{[(1S)-1-Methylbutyl]oxy}-9-{[1-(1-methylethyl)-4-piperidinyl]methyl}-8-(methyloxy)-9H-purin-6-amine

HRID 1044907Notes

Reaction equation

HRID 1044907 reaction equation
C(N1CC[CH2:6][CH:5](CCN2C(OC)=NC3C2=NC(O[C@@H](C)CCC)=NC=3N)[CH2:4]1)C.[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:51][CH3:52])[N:41]2[CH2:44][CH:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)=[C:37]([NH2:53])[N:36]=1)[CH2:31][CH2:32][CH3:33].IC(C)C>>[CH3:29][C@H:30]([O:34][C:35]1[N:43]=[C:42]2[C:38]([N:39]=[C:40]([O:51][CH3:52])[N:41]2[CH2:44][CH:45]2[CH2:46][CH2:47][N:48]([CH:5]([CH3:6])[CH3:4])[CH2:49][CH2:50]2)=[C:37]([NH2:53])[N:36]=1)[CH2:31][CH2:32][CH3:33]

Participants

4

Procedure

Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine and 2-iodopropane.

Sources & evidence

ORD record
ord-85c89abc73b64091838416ef803129c3
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

Loading…