phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate → 2-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

HRID 1044909Notes

Reaction equation

HRID 1044909 reaction equation
C(OC1N=C2C(N=C(OC)N2CCCC2CCCCN2)=C(N)N=1)CCC.[NH2:27][C:28]1[N:36]=[C:35]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[N:34]=[C:33]2[C:29]=1[N:30]=[C:31]([O:60][CH3:61])[N:32]2[CH2:42][CH2:43][CH:44]1[CH2:49][CH2:48][N:47](C(OCC2C=CC=CC=2)=O)[CH2:46][CH2:45]1>>[CH2:38]([O:37][C:35]1[N:34]=[C:33]2[C:29]([N:30]=[C:31]([O:60][CH3:61])[N:32]2[CH2:42][CH2:43][CH:44]2[CH2:45][CH2:46][NH:47][CH2:48][CH2:49]2)=[C:28]([NH2:27])[N:36]=1)[CH2:39][CH2:40][CH3:41]

Participants

3

Reactant 2

HCID 58306071phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 583061842-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine

Product 1

HCID 583062442-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 32 from phenylmethyl 4-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate.

Sources & evidence

ORD record
ord-9c5fa11f9cfb431d9c67849a736c529a
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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