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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044911Generated: November 1, 2026

Benzyl 4-(2-bromoethyl)piperidine-1-carboxylate → Phenylmethyl 4-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044911

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 4-(2-bromoethyl)piperidine-1-carboxylateHCID 11056468—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178448286HCID 178448286—
ProductPhenylmethyl 4-{2-[6-amino-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 58306076—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine trifluoroacetate salt and phenylmethyl 4-(2-bromoethyl)-1-piperidinecarboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-f9031ddb8d874e589e3e71a428e49b08
Source noteuspto-grants-2013_10