Isopropyl iodide → 2-{[(1S)-1-Methylbutyl]oxy}-9-{2-[1-(1-methylethyl)-4-piperidinyl]ethyl}-8-(methyloxy)-9H-purin-6-amine

Participants

Role	Name	HCID	Charge
Reactant	Isopropyl iodide	HCID 6362	—
Reactant	9-[2-(1-Ethyl-3-piperidinyl)ethyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine	HCID 58306212	—
Reactant	2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine	HCID 58306232	—
Product	2-{[(1S)-1-Methylbutyl]oxy}-9-{2-[1-(1-methylethyl)-4-piperidinyl]ethyl}-8-(methyloxy)-9H-purin-6-amine	HCID 58306223	—

Reaction Steps

Prepared similarly to Intermediate 46 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine and 2-iodopropane. LCMS (System B): tRET=1.27 min; MH+ 405

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08563717B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-3b6a649efd70410996b3dd7f04e936b2
Source note	uspto-grants-2013_10