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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044921Generated: October 30, 2026

Phenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylate → Phenylmethyl 4-{4-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044921

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylateHCID 11046432—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178450370HCID 178450370—
ProductPhenylmethyl 4-{4-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylateHCID 58306104—

Reaction Steps

Prepared similarly to Intermediate 31 from 2-(butyloxy)-8-(methyloxy)-9H-purin-6-amine trifluoroacetate and phenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylate. LCMS (System B): tRET=3.23 min; MH+ 511

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-0731b558031b4dd5901be40468af7957
Source noteuspto-grants-2013_10