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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1044926Generated: November 1, 2026

Phenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylate → Phenylmethyl 4-{4-[6-amino-2-(butylamino)-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylate

https://huagongshe.com/reaction/1044926

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylateHCID 11046432—
ReactantPhenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylateHCID 58306132—
ReactantHCID 178448879HCID 178448879—
ProductPhenylmethyl 4-{4-[6-amino-2-(butylamino)-8-(methyloxy)-9H-purin-9-yl]butyl}-1-piperidinecarboxylateHCID 58306197—

Reaction Steps

Prepared similarly to Intermediate 31 from N2-butyl-8-methoxy-9H-purine-2,6-diamine trifluoroacetic acid salt and phenylmethyl 4-(4-bromobutyl)-1-piperidinecarboxylate. LCMS (System B): tRET=2.64 min; MH+ 510

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08563717B2
Source datasetuspto-grants-2013_10
ORD IDord-3d151b6ad6ef4e3288fe1c339f2af63d
Source noteuspto-grants-2013_10