2-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine → 2-(Butyloxy)-8-(methyloxy)-9-[6-(4-piperidinyl)hexyl]-9H-purin-6-amine
Reaction equation
C(OC1N=C2C(N=C(OC)N2CCCC2CCCCN2)=C(N)N=1)CCC.[NH2:27][C:28]1[N:36]=[C:35]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[N:34]=[C:33]2[C:29]=1[N:30]=[C:31]([O:64][CH3:65])[N:32]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]1[CH2:53][CH2:52][N:51](C(OCC2C=CC=CC=2)=O)[CH2:50][CH2:49]1>>[CH2:38]([O:37][C:35]1[N:34]=[C:33]2[C:29]([N:30]=[C:31]([O:64][CH3:65])[N:32]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH:48]2[CH2:49][CH2:50][NH:51][CH2:52][CH2:53]2)=[C:28]([NH2:27])[N:36]=1)[CH2:39][CH2:40][CH3:41]Participants
3
Procedure
Prepared similarly to Intermediate 32 from phenylmethyl 4-{6-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]hexyl}-1-piperidinecarboxylate.
Sources & evidence
- ORD record
- ord-0e4fb3e3dbea4634813ef9b084540163
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08563717B2
Reaction notes
Loading…