Hydrochloric Acid → 6-Amino-2-(butyloxy)-9-[3-(2-piperidinyl)propyl]-7,9-dihydro-8H-purin-8-one

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Reaction Steps

2-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine (41.89 mg, 0.116 mmol) in methanol (3 ml) was treated with 4 molar HCl solution in 1,4-dioxane (0.722 mL, 2.89 mmol) and stirred at ambient temperature in a capped vial overnight. The clear reaction solution was blown down under N2 and then dissolved in 1 ml 1:1 DMSO:MeOH and purified by MDAP (Method A). The appropriate fraction was evaporated under N2 in a Radleys blow down unit to afford the title compound as a white solid (31.1 mg).

Provenance & Evidence