1-Bromo-3-methylbutane → 6-Amino-2-(butyloxy)-9-{[1-(3-methylbutyl)-3-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

HRID 1044964Notes

Reaction equation

HRID 1044964 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:22]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]2)=[C:8]([NH2:24])[N:7]=1)[CH2:2][CH2:3][CH3:4].Br[CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29]>>[NH2:24][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:22])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[CH2:17]1

Participants

3

Reactant 2

HCID 78911-Bromo-3-methylbutaneHCID 583062412-butoxy-8-methoxy 9-(piperidin-3-ylmethyl)-9H-purin-6-amine

Product 1

HCID 672336706-Amino-2-(butyloxy)-9-{[1-(3-methylbutyl)-3-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 24 from 2-(butyloxy)-8-(methyloxy)-9-(3-piperidinylmethyl)-9H-purin-6-amine and 1-bromo-3-methylbutane.

Sources & evidence

ORD record
ord-c9286cfab36646fdb1e42ff942f3384f
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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