Iodocyclopentane → 6-Amino-2-(butyloxy)-9-[2-(1-cyclopentyl-3-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

HRID 1044972Notes

Reaction equation

HRID 1044972 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:18]1

Participants

3

Reactant 2

HCID 73784IodocyclopentaneHCID 583062622-(Butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine

Product 1

HCID 672328846-Amino-2-(butyloxy)-9-[2-(1-cyclopentyl-3-piperidinyl)ethyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine and iodocyclopentane.

Sources & evidence

ORD record
ord-f70eb1f515d449828ce9e2776f536590
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

Loading…