(Iodomethyl)cyclopentane → 6-Amino-2-(butyloxy)-9-{2-[1-(cyclopentylmethyl)-3-piperidinyl]ethyl}-7,9-dihydro-8H-purin-8-one
Reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH2:27][CH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:27][CH:28]2[CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:18]1Participants
3
Procedure
Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[2-(3-piperidinyl)ethyl]-9H-purin-6-amine and (1-iodomethyl)cyclopentane.
Sources & evidence
- ORD record
- ord-6932791fad7f4cc2a7266e7890f35c99
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08563717B2
Reaction notes
Loading…