Isobutyl iodide → 6-Amino-2-(butyloxy)-9-{[1-(2-methylpropyl)-4-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

HRID 1044993Notes

Reaction equation

HRID 1044993 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:22]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[C:8]([NH2:24])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH2:26][CH:27]([CH3:29])[CH3:28]>>[NH2:24][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:22])[N:12]2[CH2:15][CH:16]1[CH2:17][CH2:18][N:19]([CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 10556Isobutyl iodideHCID 583062032-(Butyloxy)-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine

Product 1

HCID 672332916-Amino-2-(butyloxy)-9-{[1-(2-methylpropyl)-4-piperidinyl]methyl}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 24 from 2-(butyloxy)-8-(methyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine and 1-iodo-2-methylpropane.

Sources & evidence

ORD record
ord-3e01fcb277d049c9a1c4828de9dae5e2
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

Loading…