Isobutyl iodide → 6-Amino-2-(butyloxy)-9-{3-[1-(2-methylpropyl)-4-piperidinyl]propyl}-7,9-dihydro-8H-purin-8-one

HRID 1045008Notes

Reaction equation

HRID 1045008 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH2:28][CH:29]([CH3:31])[CH3:30]>>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:19][CH2:20][N:21]([CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 10556Isobutyl iodideHCID 583061262-(Butyloxy)-8-(methyloxy)-9-[3-(4-piperidinyl)propyl]-9H-purin-6-amine

Product 1

HCID 672344506-Amino-2-(butyloxy)-9-{3-[1-(2-methylpropyl)-4-piperidinyl]propyl}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[3-(4-piperidinyl)propyl]-9H-purin-6-amine and 1-iodo-2-methylpropane.

Sources & evidence

ORD record
ord-df11f71bfa4142a081ce76f739a6c36e
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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