Iodocyclopentane → 6-Amino-2-(butyloxy)-9-[4-(1-cyclopentyl-4-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

HRID 1045019Notes

Reaction equation

HRID 1045019 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4].I[CH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[NH2:27][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:25])[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:20][CH2:21][N:22]([CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 73784IodocyclopentaneHCID 583062222-(Butyloxy)-8-(methyloxy)-9-[4-(4-piperidinyl)butyl]-9H-purin-6-amine

Product 1

HCID 671819116-Amino-2-(butyloxy)-9-[4-(1-cyclopentyl-4-piperidinyl)butyl]-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 80 from 2-(butyloxy)-8-(methyloxy)-9-[4-(4-piperidinyl)butyl]-9H-purin-6-amine and iodocyclopentane.

Sources & evidence

ORD record
ord-71ed6892be744a0fb67484a5591a14b8
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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