1-Bromo-3-methylbutane → 6-amino-2-(butyloxy)-9-{5-[1-(3-methylbutyl)-4-piperidinyl]pentyl}-7,9-dihydro-8H-purin-8-one

HRID 1045027Notes

Reaction equation

HRID 1045027 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:26]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[C:8]([NH2:28])[N:7]=1)[CH2:2][CH2:3][CH3:4].Br[CH2:30][CH2:31][CH:32]([CH3:34])[CH3:33]>>[NH2:28][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:26])[N:12]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH:20]1[CH2:21][CH2:22][N:23]([CH2:30][CH2:31][CH:32]([CH3:34])[CH3:33])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 78911-Bromo-3-methylbutaneHCID 583060862-(Butyloxy)-8-(methyloxy)-9-[5-(4-piperidinyl)pentyl]-9H-purin-6-amine

Product 1

HCID 671829386-amino-2-(butyloxy)-9-{5-[1-(3-methylbutyl)-4-piperidinyl]pentyl}-7,9-dihydro-8H-purin-8-one

Procedure

Prepared similarly to Example 14 from 2-(butyloxy)-8-(methyloxy)-9-[5-(4-piperidinyl)pentyl]-9H-purin-6-amine and 1-bromo-3-methylbutane.

Sources & evidence

ORD record
ord-8b06457b4579492d90b9ea61fd85c1e6
Source dataset
uspto-grants-2013_10
Patent number
US08563717B2

Reaction notes

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