HCID 68956549, compound → HCID 68654072, compound

HRID 1045030Notes

Reaction equation

HRID 1045030 reaction equation
C([O:8][C:9](=[O:26])[CH2:10][C:11]1[CH:12]=[C:13]([CH:23]=[CH:24][CH:25]=1)[O:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21]C)=[O:19])C1C=CC=CC=1>CO.[Pd]>[CH3:21][O:20][C:18](=[O:19])[CH2:17][CH2:16][CH2:15][O:14][C:13]1[CH:12]=[C:11]([CH2:10][C:9]([OH:26])=[O:8])[CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 1

HCID 68956549HCID 68956549, compound

Product 1

HCID 68654072HCID 68654072, compoundYield 68.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture of ethyl 4-(3-(2-(benzyloxy)-2-oxoethyl)phenoxy)butanoate (2.05 g, 5.77 mmol) and Pd/C (0.207 g) in methanol was stirred at room temperature under H2 overnight. The mixture was filtered and the filtrate was concentrated under reduce pressure. The residue was washed with ether, filtrated and dried to obtain 2-(3-(4-methoxy-4-oxobutoxy)phenyl)acetic acid (compound 0202-35) (1 g, 66%): LCMS: 267 [M+1]+.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. washThe residue was washed with ether
  4. filtrationfiltrated
  5. customdried

Sources & evidence

ORD record
ord-32ff7247a0854a389a7a3231a183426d
Source dataset
uspto-grants-2013_10
Patent number
US08563741B2

Reaction notes

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