Ammonia → HCID 44540523, compound

Participants

Reaction Steps

2.1 ml of ammonia in methanol (7M) is added at ambient temperature to a solution of 1.85 g of 2-bromo-6-cyano-benzenesulfonyl chloride in 40 ml of tetrahydrofurane. The reaction mixture is stirred for 16 hours at ambient temperature. Then the mixture is poured into water and extracted with ethylacetate. The organic layer is washed with water, dried over sodium sulfate, filtered and concentrated. Chromatography of the residue with cyclohexane—ethyl acetate (1:1) affords 730 mg of 7-bromo-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-ylamine (P1.1).

Provenance & Evidence