Potassium Phosphate, Tribasic → HCID 44540525, compound

Participants

Reaction Conditions

Reaction Steps

170 mg of 7-bromo-1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-ylamine, 119 mg of phenylboronic acid, 10 mg of palladium(II)acetate, 21 mg of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl and 415 mg of potassium phosphate are suspended in 5 ml of toluene. The mixture is stirred under an argon athmosphere at 100° C. for 16 h. The reaction mixture is poured into water and extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and evaporated. Chromatographie of the residue with cyclohexane—ethyl acetate (1:1) affords 41 mg of 1,1-dioxo-7-phenyl-1H-1λ6-benzo[d]isothiazol-3-ylamine (P1.5).

Provenance & Evidence