Dimethyl Sulfoxide → 3-((6-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(cyclopropyl)amino)propanenitrile

HRID 104506Notes

Reaction equation

HRID 104506 reaction equation
[CH3:42][S:43]([CH3:44])=[O:45].[CH:34]1([NH:37][CH2:38][CH2:39][C:40]#[N:41])[CH2:35][CH2:36]1.[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2)(=[O:32])=[O:33]>>[c:7]1([N:37]([CH:34]2[CH2:35][CH2:36]2)[CH2:38][CH2:39][C:40]#[N:41])[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 1435373-(Cyclopropylamino)propionitrileHCID 593337606-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate

Product 1

HCID 461984783-((6-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)(cyclopropyl)amino)propanenitrile

Sources & evidence

ORD record
ord-e67f919e2c7744808993ae2c84879e06
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…