Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Reactant | Cyclohexanone, 4,4-dimethyl- | HCID 138166 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67179295 | HCID 67179295 | 14% |
Reaction Steps
To a toluene (5 mL) solution containing 4,4-dimethyl-cyclohexanone (500 mg, 4.0 mmol) was added methyl (triphenylphosphoranylidene)acetate (2.0 g, 6.0 mmol) and the reaction was heated to 60-70° C. for 48 h. The reaction was monitored by TLC. The reaction was cooled to room temperature, diluted with dichloromethane, washed with water, concentrated under vacuum, and the crude product was purified on a silica gel column to afford (4,4-dimethyl-cyclohexylidene)-acetic acid methyl ester (100 mg, 14% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08563742B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-34fbe80e1a2047908d5328fced50b0da |
|---|
| Source note | uspto-grants-2013_10 |
|---|
