Tetrahydrofuran → (R)-Phenyl(p-tolyl)methanol

Participants

Reaction Steps

An operation was carried out in the same manner as in Example 1, except that 0.40 mL (0.40 mmol) of an anhydrous THF solution (1.0 mol/L) of phenylmagnesium bromide was used instead of the anhydrous 1,4-dioxane solution of diphenylmagnesium. Thus, (R)-4-methylbenzhydrol was obtained. The conversion rate of the raw material was 98%, while the enantiomeric excess was 39% ee.

Provenance & Evidence