HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(triisopropylsilyl)-1H-indol-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Triisopropylsilyl chloride | HCID 139400 | — |
| Reactant | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(triisopropylsilyl)-1H-indol-6-ol | HCID 67226331 | — |
Reaction Steps
6-Benzyloxy-indole (1.0 g) was treated with NaH (135 mg) and triisopropylsilyl chloride (1.0 g) in tetrahydrofuran for 1 hour, purified by flash chromatography (98/2 ethyl acetate/hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563735B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-4409a35138d240df952f8b1534bc258c |
| Source note | uspto-grants-2013_10 |