HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1045170Generated: October 26, 2026
4-Chloro-3-nitrobenzenesulfonamide → 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide
https://huagongshe.com/reaction/1045170
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(2-Methoxyethyl)piperidin-4-amine | HCID 20119121 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-3-nitro-benzenesulfonamide | HCID 68406613 | — |
Reaction Steps
1-(2-Methoxy-ethyl)-piperidin-4-ylamine (2.01 g) and triethylamine (3.24 mL, 2.35 g) were added to 1,4-dioxane (60 mL). 4-Chloro-3-nitrobenzenesulfonamide (2.50 g) was added, and the mixture was heated to 90° C. for 16 hours. The mixture was cooled and the material purified by flash column chromatography on silica gel using 10% methanol in dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08563735B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-a6b5bf291025495f988d01fb4f4e5589 |
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| Source note | uspto-grants-2013_10 |
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