HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-(4-Chlorophenyl)-2-fluoro-5-methylpyridine | HCID 67225918 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine | HCID 67227341 | — |
Reaction Steps
A mixture of EXAMPLE 307A (1.2 g), N-bromosuccinimide (1.06 g) and AIBN (azobisisobutyronitrile) (0.178 g) in CCl4 (30 mL) was heated under reflux for 6 hours. After cooling, the solid was filtered off The filtrate was concentrated and loaded onto a silica gel column eluting with 3% ethyl acetate in hexanes to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563735B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-9eddeddba7634b4aaf37db7add2c5432 |
| Source note | uspto-grants-2013_10 |