Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 1045206Notes

Reaction equation

HRID 1045206 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Product 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
85 °C

Procedure

To a mixture of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The mixture was stirred at 85° C. for three hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Sources & evidence

ORD record
ord-a6f10b693ad6491b9dcc91137cfec540
Source dataset
uspto-grants-2013_10
Patent number
US08563735B2

Reaction notes

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