Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,1-Difluoro-2-iodoethane | HCID 3833565 | — |
| Reactant | HCID 67126454 | HCID 67126454 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 87279422 | HCID 87279422 | — |
Reaction Steps
To a solution of EXAMPLE 415B (633 mg) in anhydrous N,N-dimethylformamide (10 mL) was added sodium carbonate (254 mg) and 2,2-difluoroethyl iodide (422 mg). After stirring at 110° C. for 48 hours, the mixture was concentrated. The residue was mixed with water (20 mL) and extracted with ethyl acetate. The crude product was purified on a silica gel column eluting with 10% methanol in methylene chloride to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08563735B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-893c4c490f0440dd9d6de168995faec3 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
