HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-Chloro-6-(1-cyclopropylpiperidin-4-ylamino)pyridine-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5,6-Dichloropyridine-3-sulfonamide | HCID 4730921 | — |
| Reactant | 1-Cyclopropylpiperidin-4-amine | HCID 16227644 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Chloro-6-(1-cyclopropylpiperidin-4-ylamino)pyridine-3-sulfonamide | HCID 67169233 | — |
Reaction Steps
A mixture of EXAMPLE 387A (0.4 g), 1-cyclopropylpiperidin-4-amine (0.3 g) and N,N-diisopropylethylamine (0.37 mL) in dioxane (3 mL) was heated at 100° C. for 18 hours. The crude product was isolated by concentration and was purified on silica gel, which was eluted with ethyl acetate to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08563735B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-aeaa94dcbce3424885d8a4ab58e264e6 |
| Source note | uspto-grants-2013_10 |