1,4-Dioxaspiro[4.5]decan-8-one → HCID 59030604, compound

Participants

Reaction Conditions

Reaction Steps

1,4-Dioxaspiro[4.5]decan-8-one (2 g, 12.80 mmol) was dissolved in dry tetrahydrofuran (20 mL). The reaction mixture was cooled to −78° C. Cyclopropylmagnesium bromide (51.2 mL, 25.61 mmol) was added dropwise over a period of 10 min. The reaction mixture was stirred for 4 h, quenched with sat. NH4Cl and extracted with ethyl acetate. The solvent was evaporated and the crude product was used without further purification in the next step.

Provenance & Evidence