HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-[N'-(acetyloxy)carbamimidoyl]phenyl acetate | HCID 86663307 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl acetate | HCID 66797955 | — |
Reaction Steps
To a solution of 9.40 g (39.8 mmol) of the product obtained in Step B above in 300 ml of toluene there are added 150 mg of para-toluenesulphonic acid and the reaction mixture is heated at reflux, using a Dean-Stark system, for 12 hours. The title product is obtained after evaporating off the toluene using a rotary evaporator.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569285B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-b1229a4f7baa4ec88e9c60ea1f2dcb4d |
| Source note | uspto-grants-2013_10 |