Hydrogen Bromide → HCID 54441049, compound

Participants

Reaction Conditions

Reaction Steps

The product obtained in Step A above (250 mg, 1.13 mmol) is suspended in 10 ml of aqueous 48% HBr solution, and the reaction mixture is stirred overnight at 115° C. After cooling to ambient temperature, the mixture is poured into 10 ml of 10% NaHCO3 solution. The pH is adjusted to 7 and the aqueous phase is extracted with ethyl acetate. The organic phase is washed (saturated NaCl) and dried (MgSO4) to yield, after filtration and evaporation, the title product in the form of a white solid.

Provenance & Evidence