4-Bromoanisole → 5-Bromo-2-methoxybenzene-1-sulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

To chlorosulphonic acid (140 mL, 2 mol), cooled to 0-5° C., there added dropwise 35 ml (0.279 mol) of 4-bromoanisole. The solution is stirred for 30 minutes at 0° C. and then for about 16 hours at ambient temperature; it is poured slowly onto ice and is then stirred for a few more minutes. The white precipitate formed is filtered off and then washed with copious amounts of water.

Provenance & Evidence