p-Toluenesulfonic acid → HCID 56942859, compound

Participants

Reaction Steps

To a solution of 390 mg (0.99 mmol) of the product obtained in Step B above in 50 ml of toluene there are added 35 mg of para-toluenesulphonic acid and the reaction mixture is heated at reflux using a Dean-Stark system for 12 hours. After evaporation, the crude reaction product is purified over silica gel eluting with a mixture of CH2Cl2/AcOEt 9/1 to yield the expected product.

Provenance & Evidence