Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 66926372 | HCID 66926372 | — |
| Reactant | 1265634-91-0 | HCID 70497178 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 50917438 | HCID 50917438 | 20.8% |
Reaction Steps
19 (40.0 mg, 0.20 mmol), N-(4-amino-3-fluorophenyl)-3-fluorobenzamide (50.2 mg, 0.20 mmol), and HCl (51.0 μl, 0.18 mol) were suspended in NMP (1 mL), and stirred for 1 h at 170° C. in a microwave. The resulting mixture was purified by HPLC to provide 20 (17 mg, 20% yield) as a solid. LC-MS (M+H=410, obsd.=410).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08569295B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-610be19419ed4aa89f789aa3ada3d860 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
