HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-fluoro-N-(4-(5-oxo-3, 5,6,10b-tetrahydro-2H-oxazolo[3,2-c]pyrido[3,2-e]pyrimidin-10-ylamino)phenyl)-2-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N-(4-Aminophenyl)-4-fluoro-2-trifluoromethyl-benzamide | HCID 44603462 | — |
| Reactant | HCID 70498679 | HCID 70498679 | — |
| Product | 4-fluoro-N-(4-(5-oxo-3, 5,6,10b-tetrahydro-2H-oxazolo[3,2-c]pyrido[3,2-e]pyrimidin-10-ylamino)phenyl)-2-(trifluoromethyl)benzamide | HCID 70498042 | — |
Reaction Steps
42 (16 mg, 0.07 mmol), N-(4-aminophenyl)-4-fluoro-2-(trifluoromethyl) benzamide (22 mg, 0.07 mmol), and 4.0M HCl in dioxane (18 μl, 0.07 mmol) were suspended in a sealed tube, and placed in microwave at 140° C. for 1 h. The crude product was purified directly via HPLC to provide 43. LC-MS (M+H=488, obsd.=488).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569295B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-007376d335dc4a8891589c5bdfb48683 |
| Source note | uspto-grants-2013_10 |